This paper examines human security, and women and children’s coping capacities in armed conflict in Anglophone Cameroon. Using a qualitative research approach, the paper reveals that women and children caught in the conflict face security challenges regarding food, health, finances, personal and community safety, education, political rights and freedoms. To cope with these challenges, they rely on humanitarian organisations, well-wishers and neighbours for help. In addition, some affected women have resorted to prostitution while children go to school without uniforms, especially in remote areas. In extreme situations, others have sought refuge in the bushes, neighbouring Francophone regions, Nigeria and beyond. By zooming in on Anglophone Cameroon, whose ongoing separatist conflict and its impact on human security continues to receive scant attention in scholarship, this paper adds to existing research on human security in contexts of fragility and conflict.